Since March 2015, the highly pathogenic avian influenza (HPAI) of the H5N1 subtype has caused 37 poultry outbreaks in the Gaza Strip and required culling operations on 52 premises, resulting in the destruction of 66,243 poultry under standard disease control measures. H5N1 HPAI, also known as ‘bird flu’, affects poultry and is often lethal, endangering farmer livelihoods and presenting significant risks to the poultry sector, as well as the country as a whole, through negative implications for food safety and trade economies. In rare instances, H5N1 has caused human infections, sometimes leading to serious illness and even death; although no human infections have yet been identified in Gaza.