In December 2016, the Humanitarian Country Team (HCT) in the occupied Palestinian territory (oPt) launched its Humanitarian Response Plan (HRP) for 2017. Since then, the situation in the Gaza Strip has significantly worsened, due to a dramatic deterioration in the energy situation and other developments related to internal Palestinian dynamics, affecting the entire population of two million people. In response, the HCT, including UNRWA, has identified the following top priority, life-saving interventions needed in the Health, WASH and Food Security sectors to address the most acute humanitarian needs today. Many of these interventions were previously included in the 2017 HRP but remain unfunded despite the added urgency. Other interventions are new interventions that will now be added to the HRP to address the changing humanitarian context. These prioritized funding requirements amount to US $25.2 million. Failure to respond to these needs will exacerbate human suffering and increase the risk of a new round of violence.